SELECTED PUBLICATIONS
- Teufl M, Zajc CU, Traxlmayr MW. Engineering Strategies to Overcome the Stability-Function Trade-Off in Proteins., ACS Synthetic Biology, 2022 March, DOI: 10.1021/acssynbio.1c00512
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Zajc CU, Teufl M, Traxlmayr MW. Affinity and Stability Analysis of Yeast Displayed Proteins Methods in Molecular Biology 2022 DOI: 10.1007/978-1-0716-2285-8_9
- Zajc CU, Salzer B, Taft JM, Reddy ST, Lehner M, Traxlmayr MW. Driving CARs with alternative navigation tools - the potential of engineered binding scaffolds. FEBS J. 2020 Aug 13. doi: 10.1111/febs.15523. Online ahead of print.PMID: 32794303 Review.
- B Salzer, C M Schueller, C U Zajc, T Peters, M A Schoeber, B Kovacic, M C. Buri, E Lobner, O Dushek, J Huppa, C Obinger, E M Putz, W Holter, M W Traxlmayr*, M Lehner*, Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Nature Communications 20th August 2020; https://rdcu.be/b6nrm, https://www.nature.com/articles/s41467-020-17970-3
- Zajc (neé Brey) CU., M. Dobersberger, I. Schaffner, G. Mlynek, D. Pühringer, B. Salzer, K. Djinović-Carugo, Steinberger P, De Sousa Linhares A, Yang NJ, C. Obinger, W. Holter, MW. Traxlmayr & M. Lehner. A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. PNAS. 2020; doi.org/10.1073/pnas.1911154117
- Pascoal S, Salzer B, Scheuringer E, Wenninger-Weinzierl A, Sturtzel C, Holter W, Taschner-Mandl S, Lehner M, Distel M. A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Cancers. 2020;12(3):567
PREVIOUS PUBLICATIONS
- Proff J., CU. Brey, A. Ensser, W. Holter, M. Lehner. Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2-CH3 IgG spacer domains. J.Transl.Med. 2018. 16:26.
- Brey CU., J. Proff, N. Teufert, B. Salzer, J. Brozy, M. Münz, J. Pendzialek, A. Ensser, W. Holter, M. Lehner. A gB/CD3 bispecific BiTE antibody construct for targeting Human Cytomegalovirus-infected cells. Sci.Rep. 2018. 8:28:17453.
- Kauke MJ, Traxlmayr MW, Parker JA, Kiefer JD, Knihtila R, McGee J, Verdine G, Mattos C, Wittrup KD. An engineered protein antagonist of K-Ras/B-Raf interaction. Sci Rep. 2017;7(1):5831
- Traxlmayr MW, Shusta EV. Directed Evolution of Protein Thermal Stability Using Yeast Surface Display. Methods Mol Biol. 2017;1575:45-65.
- Traxlmayr MW, Kiefer JD, Srinivas RR, Lobner E, Tisdale AW, Mehta NK, Yang NJ, Tidor B, Wittrup KD. Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library. J Biol Chem. 2016;291(43):22496-22508.
- Traxlmayr MW, Lobner E, Hasenhindl C, Stadlmayr G, Oostenbrink C, Rüker F, Obinger C. Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution. Biotechnol J. 2014;9(8):1013-22.
- Lehner M., G. Götz, J. Proff, N. Schaft, J. Dörrie, F. Full, A. Ensser, Y.A. Muller, A. Cerwenka, H. Abken, O. Parolini, P.F. Ambros, H. Kovar, W. Holter. Redirecting T cells to Ewing´s sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection. PLoS ONE 2012. 7: e31210.
- Traxlmayr MW, Hasenhindl C, Hackl M, Stadlmayr G, Rybka JD, Borth N, Grillari J, Rüker F, Obinger C. Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing. J Mol Biol. 2012;423(3):397-412.